Low-level laser therapy (LLLT) known as “cold laser therapy” because the level of light is low which isn’t enough to heat your body’s tissue. LLLT is a form of light treatment for hair loss in men and women. This is a US FDA-cleared solution that uses clinical-strength laser technology, for genetic or hereditary; male and female pattern hair loss.

LLLT is also known as Photobiomodulation (PBM Therapy), photobiostimulation, red light therapy; use of photons at a non-thermal irradiance to alter biological activity. LLLT uses either coherent light sources (lasers) or non-coherent light sources consisting of filtered lamps or light-emitting diodes (LED) or, on occasion, a combination of both and the wavelength used are 420,530,590,640,670,880. LLLT involves exposing cells or tissue to low levels of red and near-infrared (NIR) light and over injuries or lesions to improve wound and soft tissue healing, reduce inflammation and give relief for both acute and chronic pain.

The LLLT irradiates diode rays, which penetrate the scalp to treat hair loss. LLLT for hair loss emits the wavelength of infrared light is 630-670 nanometres

low level laser therapy

The LLLT treatment is non-invasive, safe, and pain-free light technology to stimulate the hair follicle. It’s a supportive evidence-based therapy to the supplementary or medicines such as minoxidil and finasteride. However, it is non-invasive to other interventional treatments (mesotherapy, PRP, or hair transplant) of hair loss.

The LLLT uses low-levels of red and near-infrared (NIR) light, which reduces inflammation and tends to improve wound; that’s why it can be used after hair transplant surgery to fasten the soft tissue healing and enhance hair growth.

There are different LLLT devices available in the market as:

  Professional machines with overhead panels

  Home or Hand-held devices:

  Head Caps

  Head helmet

  Comb or Brush

LLLT used in a coherent light source such as 308 Excimer, targeted Phototherapy (Daavlin), helium-neon (632.8 nm), and fractional erbium-glass (1550 nm). This explains the extensive use of these devices in hair growth.

LLLT is advised twice or thrice a week for a period of 3 to 9 months. Professionals therapy at a medical centre and handheld at home are administered respectively, for a period of 10 to 15 minutes the scalp is exposed to laser-emitting diodes.

Moreover, massage of the scalp along with therapy promotes blood circulation and enhances the effectiveness of LLLT.

Ideal patients with hair loss

Patients with hormonal and genetic influence (androgenetic alopecia) or pattern hair loss are ideal candidates for LLLT.

Hair professionals usually recommend for mild to medium degree of hair loss.

Type I to Type V Norwood-Hamilton Classification.

hair rich

Woman with Type I & II Ludwig scale.

hair rich

Mechanism of action

Low-level laser therapy uses photons at a non-thermal irradiance to alter the biological activity of scalp cells or tissues. The photons emitted by the low-level laser beams acts on:

1. Release of nitric oxide from the targeted scalp cells. Nitric oxide increases blood flow or vasculature of the scalp; which helps in the supply of oxygen and nutrients to the hair root or follicle. Hence, it reduces the peri-follicular inflammation responsible for the initiation of hair loss.

2. It acts on enzyme cytochrome C oxidase to produce adenosine triphosphate (ATP) which converts to cyclic AMP in the hair follicular cells. However, this releases energy and further stimulates metabolic processes necessary for the hair growth cycle.

3. DHT (dihydrotestosterone), is an androgen produced as a by-product of testosterone. In genetically susceptible to hair loss or pattern hair loss, DHT bind to receptors in the hair follicles and cause them to shrink, weaken and eventually die. LLLT works by preventing the excess build-up of DHT by blocking a step ahead in the formation

4. However, Dandruff and hair loss have a complicated relationship. Dandruff occurs when the scalp is either too oily or when it’s too dry. Dandruff is a chronic, persisting scaling of skin over the scalp, resulting in intense itching. It further urges to vigorous scratching to relieve that itch, which damages the hair follicle and results in hair loss. LLLT acts on the sebaceous glands, reducing the oiliness in the scalp and also help in reducing dandruff and dryness. LLLT is also having anti-inflammatory properties.

Let us have a look at the hair growth cycle to understand its mode of action on hair loss. 

 Growth or anagen phase

 Resting or telogen phase

 Shedding or catagen phase

LLLT by altering biological activity and increasing blood flow of scalp tissues; stimulates the metabolism in hair follicles that are in the telogen or catagen phase of the hair cycle. As of this, it stimulates the dormant hair follicle or anagen phase of the cycle to grow hair.

Advantages of LLLT:

· It is a safe and pain-free procedure.

· It is a non-invasive procedure. 

· No side-effects.

· It reduces hair fall and increases hair thickness and.

· It has perceptible hair growth after 3 to 6 months of treatment.

Moreover, certain drugs such as photosensitizing agents can have interaction with LLLT, as these drugs increase sensitivity to light therapy.